Lactobacillus acidophilus BIOTECH 1900 decreases the transepithelial mucosal-to-serosal transport of colchicine in an ex vivo non-everted gut sac model

Lactobacillus acidophilus BIOTECH 1900 decreases the transepithelial mucosal-to-serosal transport of colchicine in an ex vivo non-everted gut sac model

Abstract Colchicine (COL) is a permeability-glycoprotein (P-gp) substrate drug used for familial Mediterranean fever, acute pericarditis, and the management of acute gout. It has a narrow therapeutic index which implies that a small change in the drug’s absorption profile may lead to either toxicity...

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Bibliographic Details
Main Authors: GERWIN LOUIS T. DELA TORRE, ALICE ALMA C. BUNGAY
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2022-11-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
colchicine
HPLC-PDA
Lactobacillus acidophilus
non-everted gut sac
P-glycoprotein
probiotics
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000700902&lng=en&tlng=en

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