A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer

A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer

Chimeric antigen receptor (CAR)-T cell therapy shows excellent potency against hematological malignancies, but it remains challenging to treat solid tumors, mainly because of a lack of appropriate antigenic targets and an immunosuppressive tumor microenvironment (TME). The checkpoint molecule progra...

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Bibliographic Details
Main Authors: Dan Li, Hejiao English, Jessica Hong, Tianyuzhou Liang, Glenn Merlino, Chi-Ping Day, Mitchell Ho
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
shark VNAR
single-domain antibody
CAR-T cells
immune checkpoint
PD-L1
triple-negative breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522000328

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http://www.sciencedirect.com/science/article/pii/S2372770522000328

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