Target-Dependent Expression of IL12 by synNotch Receptor-Engineered NK92 Cells Increases the Antitumor Activities of CAR-T Cells

Target-Dependent Expression of IL12 by synNotch Receptor-Engineered NK92 Cells Increases the Antitumor Activities of CAR-T Cells

IL12 is an immune-stimulatory cytokine for key immune cells including T cells and NK cells. However, systemic administration of IL12 has serious side effects that limit its clinical application in patients. Recently, synthetic Notch (synNotch) receptors have been developed that induce transcriptiona...

Full description

Bibliographic Details
Main Authors: Hong Luo, Xiuqi Wu, Ruixin Sun, Jingwen Su, Yi Wang, Yiwei Dong, Bizhi Shi, Yansha Sun, Hua Jiang, Zonghai Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Oncology
Subjects:
IL12
synNotch receptor
NK92
CAR-T
toxicity
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01448/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01448/full

Similar Items