Investigation of the efficacy and safety of wild- type and triple-gene knockout pig RBC transfusions in nonhuman primates

Investigation of the efficacy and safety of wild- type and triple-gene knockout pig RBC transfusions in nonhuman primates

IntroductionDecreasing rates of blood donation and close margins between blood supply and demand pose challenges in healthcare. Genetically engineered pig red blood cells (pRBCs) have been explored as alternatives to human RBCs for transfusion, and triple-gene knockout (TKO) modification improves th...

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Bibliographic Details
Main Authors: Juhye Roh, Jeong Ho Hwang, Sangkeun Park, Haneulnari Lee, Eun Mi Park, Hye Won Lee, Ju Young Lee, Joohyun Shim, Kimyung Choi, Hee Jung Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Immunology
Subjects:
porcine red blood cells
xenotransfusion
transfusion
nonhuman primates
genetically modified pigs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1418249/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1418249/full

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