IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma

IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma

Abstract Background Mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), are present in most gliomas. IDH1 mutation is an important prognostic marker in glioma. However, its regulatory mechanism in glioma remains incompletely understood. Results miR-182-5p expression was increased within I...

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Bibliographic Details
Main Authors: Haiting Zhao, Li Meng, Peng Du, Xinbin Liao, Xin Mo, Mengqi Gong, Jiaxin Chen, Yiwei Liao
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Biological Research
Subjects:
Gliomas
IDH1 mutation
R-2HG
miR-182-5p
Cell cycle
CS-NPs(antagomir-182-5p)
Online Access:https://doi.org/10.1186/s40659-024-00512-2

Internet

https://doi.org/10.1186/s40659-024-00512-2

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