Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection

Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection

ABSTRACT Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified in 2012 as a novel etiological agent of severe respiratory disease in humans. As during infection by other viruses, host sensing of viral double-stranded RNA (dsRNA) induces several antiviral pathways. These includ...

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Bibliographic Details
Main Authors: Courtney E. Comar, Stephen A. Goldstein, Yize Li, Boyd Yount, Ralph S. Baric, Susan R. Weiss
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mBio
Subjects:
MERS-CoV
coronavirus
interferon antagonist
viral accessory proteins
Online Access:https://journals.asm.org/doi/10.1128/mBio.00319-19

Internet

https://journals.asm.org/doi/10.1128/mBio.00319-19

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