Insulin receptor loss impairs mammary tumorigenesis in mice

Insulin receptor loss impairs mammary tumorigenesis in mice

Summary: Breast cancer (BC) prognosis and outcome are adversely affected by obesity. Hyperinsulinemia, common in the obese state, is associated with higher risk of death and recurrence in BC. Up to 80% of BCs overexpress the insulin receptor (INSR), which correlates with worse prognosis. INSR’s role...

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Bibliographic Details
Main Authors: Lauren Podmore, Yekaterina Poloz, Catherine Iorio, Samar Mouaaz, Kevin Nixon, Petr Smirnov, Brianna McDonnell, Sonya Lam, Bowen Zhang, Pirashaanthy Tharmapalan, Soumili Sarkar, Foram Vyas, Marguerite Ennis, Ryan Dowling, Vuk Stambolic
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723012639

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http://www.sciencedirect.com/science/article/pii/S2211124723012639

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