Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus the antibody response in mice

Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus the antibody response in mice

We performed epitope mapping studies on the major surface glycoprotein (GP) of Ebola virus (EBOV) using Chemically Linked Peptides on Scaffolds (CLIPS), which form linear and potential conformational epitopes. This method identified monoclonal antibody epitopes and predicted additional epitopes reco...

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Bibliographic Details
Main Authors: Daniel A. J. Mitchell, Lesley C. Dupuy, Mariano Sanchez-Lockhart, Gustavo Palacios, Jaap W. Back, Katya Shimanovskaya, Sidhartha Chaudhury, Daniel R. Ripoll, Anders Wallqvist, Connie S. Schmaljohn
Format: Article
Language:English
Published: Taylor & Francis Group 2017-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
ebola virus
filovirus
dna vaccine
epitope mapping
antibody
focusing
mice
Online Access:http://dx.doi.org/10.1080/21645515.2017.1347740

Internet

http://dx.doi.org/10.1080/21645515.2017.1347740

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