Integrated analysis on transcriptome and behaviors defines HTT repeat-dependent network modules in Huntington's disease

Integrated analysis on transcriptome and behaviors defines HTT repeat-dependent network modules in Huntington's disease

Huntington's disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene. Knock-in mice carrying a CAG repeat-expanded Htt will develop HD phenotypes. Previous studies suggested dysregulated molecular networks in a CAG length genotype- and the age-dependent manner in brain tis...

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Bibliographic Details
Main Authors: Lulin Huang, Li Fang, Qian Liu, Abolfazl Doostparast Torshizi, Kai Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-03-01
Series:Genes and Diseases
Subjects:
Behaviors
CAG repeat
Huntington's disease
Mice
Single-cell RNA sequencing
Small chemicals
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304221000714

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http://www.sciencedirect.com/science/article/pii/S2352304221000714

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