Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia

Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia

Abstract The mechanism that drives the switch from fetal to adult hemoglobin (Hb) provides a therapeutic target for β-thalassemia. We have previously identified that hypermethylation of transcription factor ERF promoter reactivated γ-globin expression. To uncover the mechanism underlying the hyperme...

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Bibliographic Details
Main Authors: Xiuqin Bao, Yuanyi Gao, Zhongju Wang, Yuhua Ye, Diyu Chen, Yangjin Zuo, Cunyou Zhao, Xiangmin Xu
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Clinical Epigenetics
Subjects:
RP11-196G18.23
Fetal hemoglobin
ERF promoter hypermethylation
β-Thalassemia
γ-Globin
Online Access:https://doi.org/10.1186/s13148-023-01614-6

Internet

https://doi.org/10.1186/s13148-023-01614-6

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