Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na<sup>+</sup> Channel 1.6 Enables Isoform-Selective Modulation

Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na<sup>+</sup> Channel 1.6 Enables Isoform-Selective Modulation

Voltage-gated Na<sup>+</sup> (Na<sub>v</sub>) channels are the primary molecular determinant of the action potential. Among the nine isoforms of the Na<sub>v</sub> channel α subunit that have been described (Na<sub>v</sub>1.1-Na<sub>v</sub>...

Full description

Bibliographic Details
Main Authors: Nolan M. Dvorak, Cynthia M. Tapia, Aditya K. Singh, Timothy J. Baumgartner, Pingyuan Wang, Haiying Chen, Paul A. Wadsworth, Jia Zhou, Fernanda Laezza
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
peptidomimetics
protein–protein interactions (PPIs)
voltage-gated Na<sup>+</sup> (Na<sub>v</sub>) channels
fibroblast growth factor 14 (FGF14)
medium spiny neurons (MSNs)
nucleus accumbens (NAc)
Online Access:https://www.mdpi.com/1422-0067/22/24/13541

Internet

https://www.mdpi.com/1422-0067/22/24/13541

Similar Items