p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions

p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions

Abstract Background As an important cellular stress sensor phosphoprotein p53 can trigger cell cycle arrest and apoptosis and regulate autophagy. The p53 activity mainly depends on its transactivating function, however, how p53 can select one or another biological outcome is still a matter of profou...

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Bibliographic Details
Main Authors: Alessia Garufi, Giuseppa Pistritto, Silvia Baldari, Gabriele Toietta, Mara Cirone, Gabriella D’Orazi
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
p53
DRAM
PUMA
Autophagy
Hyperglycemia
Diabetes
Online Access:http://link.springer.com/article/10.1186/s13046-017-0596-z

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http://link.springer.com/article/10.1186/s13046-017-0596-z

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