Disulfiram Acts as a Potent Radio-Chemo Sensitizer in Head and Neck Squamous Cell Carcinoma Cell Lines and Transplanted Xenografts

Disulfiram Acts as a Potent Radio-Chemo Sensitizer in Head and Neck Squamous Cell Carcinoma Cell Lines and Transplanted Xenografts

The poor prognosis of locally advanced and metastatic head and neck squamous cell carcinoma (HNSCC) is primarily mediated by the functional properties of cancer stem cells (CSCs) and resistance to chemoradiotherapy. We investigated whether the aldehyde dehydrogenase (ALDH) inhibitor disulfiram (DSF)...

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Bibliographic Details
Main Authors: Wenhao Yao, Xu Qian, Sebastian Ochsenreither, Ferrone Soldano, Albert B. DeLeo, Holger Sudhoff, Felix Oppel, Andreas Kuppig, Konrad Klinghammer, Andreas M. Kaufmann, Andreas E. Albers
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
disulfiram
HNSCC stem cells
aldehyde dehydrogenase
cisplatin
irradiation
Online Access:https://www.mdpi.com/2073-4409/10/3/517

Internet

https://www.mdpi.com/2073-4409/10/3/517

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