Design, Synthesis and Antiproliferative Evaluation of Bis-Indole Derivatives with a Phenyl Linker: Focus on Autophagy

Design, Synthesis and Antiproliferative Evaluation of Bis-Indole Derivatives with a Phenyl Linker: Focus on Autophagy

This work deals with the study of the synthesis of new bis-indole analogues with a phenyl linker derived from indole phytoalexins. Synthesis of target bis-indole thiourea linked by a phenyl linker was achieved by the reaction of [1-(tert-butoxycarbonyl)indol-3-yl]methyl isothiocyanate with p-phenyle...

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Bibliographic Details
Main Authors: Marianna Budovska, Radka Michalkova, Martin Kello, Janka Vaskova, Jan Mojzis
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
indole phytoalexins
cell death
autophagy
GSH
lung cancer
Online Access:https://www.mdpi.com/1420-3049/28/1/251

Internet

https://www.mdpi.com/1420-3049/28/1/251

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