Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms

Abstract Rheumatoid arthritis (RA) is a common chronic inflammatory disorder that usually affects joints. It was found that roburic acid (RBA), an ingredient from anti-RA herb Gentiana macrophylla Pall., displayed strong anti-inflammatory activity. However, its medical application is limited by its...

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Bibliographic Details
Main Authors: Na Jia, Yunzhen Gao, Min Li, Yi Liang, Yuwen Li, Yunzhu Lin, Shiqi Huang, Qing Lin, Xun Sun, Qin He, Yuqin Yao, Ben Zhang, Zhirong Zhang, Ling Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01499-0