Production of nanostructured molecular liquids by supercritical CO2 processing

Stable molecular clusters of ibuprofen and naproxen were prepared in dry ice, by supersonic jet expansion of their supercritical CO2 drug formulations into a liquid nitrogen cooled collection vessel, with up to 80% yield. Mixing the “dry ice” in water, resulted in the solubilization of the clusters...

Full description

Bibliographic Details
Main Authors: Sudhir Kumar Sharma, Abiy D. Woldetsadik, Thomas Blanton, Matthew J. O'Connor, Mazin Magzoub, Ramesh Jagannathan
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:OpenNano
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352952016300123