Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

Somatosensory information is processed by a complex network of interneurons in the spinal dorsal horn. It has been reported that inhibitory interneurons that express neuropeptide Y (NPY), either permanently or during development, suppress mechanical itch, with no effect on pain. Here, we investigate...

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Bibliographic Details
Main Authors: Kieran A Boyle, Erika Polgar, Maria Gutierrez-Mecinas, Allen C Dickie, Andrew H Cooper, Andrew M Bell, Evelline Jumolea, Adrian Casas-Benito, Masahiko Watanabe, David I Hughes, Gregory A Weir, John S Riddell, Andrew J Todd
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
NPY
chemogenetics
neuropathic pain
inflammatory pain
pruritogen
Online Access:https://elifesciences.org/articles/86633

Internet

https://elifesciences.org/articles/86633

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