Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis
The transcription factor Grhl3 is known to play a role in the nucleus during epidermal differentiation. Here, the authors report that Grhl3 is also cytoplasmic and membrane-localized, increasing mechanical stiffness by upregulating actomyosin networks.
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06171-8 |