CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock

Abstract Current biomarkers for sepsis are limited by their non-specificity, short half-life, and insensitive response to therapy. Recently, we have demonstrated that citrullinated histone H3(CitH3) is released into the blood from neutrophil extracellular traps(NETs) in response to severe infection,...

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Bibliographic Details
Main Authors: Baihong Pan, Hasan B. Alam, Wei Chong, James Mobley, Baoling Liu, Qiufang Deng, Yinjian Liang, Yanming Wang, Eric Chen, Tianbing Wang, Muneesh Tewari, Yongqing Li
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-09337-4