A novel non-sulphamoylated 2-methoxyestradiol derivative causes detachment of breast cancer cells by rapid disassembly of focal adhesions

A novel non-sulphamoylated 2-methoxyestradiol derivative causes detachment of breast cancer cells by rapid disassembly of focal adhesions

Abstract Background 2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical application. Therefore, more stable derivatives with potentially improved clinica...

Full description

Bibliographic Details
Main Authors: Mandie Botes, Tamarin Jurgens, Zohreh Riahi, Michelle Visagie, Rustelle Janse van Vuuren, Anna Margaretha Joubert, Iman van den Bout
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cancer Cell International
Subjects:
Breast cancer
2-Methoxyestradiol
Cell detachment
Focal adhesion
Online Access:http://link.springer.com/article/10.1186/s12935-018-0688-7

Internet

http://link.springer.com/article/10.1186/s12935-018-0688-7

Similar Items