Sporadic DUX4 expression in FSHD myocytes is associated with incomplete repression by the PRC2 complex and gain of H3K9 acetylation on the contracted D4Z4 allele

Sporadic DUX4 expression in FSHD myocytes is associated with incomplete repression by the PRC2 complex and gain of H3K9 acetylation on the contracted D4Z4 allele

Abstract Background Facioscapulohumeral muscular dystrophy 1 (FSHD1) has an autosomal dominant pattern of inheritance and primarily affects skeletal muscle. The genetic cause of FSHD1 is contraction of the D4Z4 macrosatellite array on chromosome 4 alleles associated with a permissive haplotype causi...

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Bibliographic Details
Main Authors: Premi Haynes, Karol Bomsztyk, Daniel G. Miller
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Epigenetics & Chromatin
Subjects:
FSHD
Facioscapulohumeral
Muscular
Dystrophy
DUX4
Epigenetics
Online Access:http://link.springer.com/article/10.1186/s13072-018-0215-z

Internet

http://link.springer.com/article/10.1186/s13072-018-0215-z

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