Tumor Cell-Specific Retention and Photodynamic Action of Erlotinib-Pyropheophorbide Conjugates

Tumor Cell-Specific Retention and Photodynamic Action of Erlotinib-Pyropheophorbide Conjugates

To enhance uptake of photosensitizers by epithelial tumor cells by targeting these to EGFR, pyropheophorbide derivatives were synthesized that had erlotinib attached to different positions on the macrocycle. Although the addition of erlotinib reduced cellular uptake, several compounds showed prolong...

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Bibliographic Details
Main Authors: Erin C. Tracy, Ravindra R. Cheruku, Ravindra K. Pandey, Heinz Baumann
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
erlotinib-conjugates
cellular uptake
subcellular deposition
photoreaction
EGFR inhibition
light-sensitive erlotinib release
Online Access:https://www.mdpi.com/1422-0067/23/19/11081

Internet

https://www.mdpi.com/1422-0067/23/19/11081

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