Heat shock protein 70 protects PC12 cells against ischemia-hypoxia/reoxygenation by maintaining intracellular Ca2+ homeostasis

Heat shock protein 70 protects PC12 cells against ischemia-hypoxia/reoxygenation by maintaining intracellular Ca2+ homeostasis

Heat shock protein 70 (HSP70) maintains Ca2+ homeostasis in PC12 cells, which may protect against apoptosis; however, the mechanisms of neuroprotection are unclear. Therefore, in this study, we examined Ca2+ levels in PC12 cells transfected with an exogenous lentiviral HSP70 gene expression construc...

Full description

Bibliographic Details
Main Authors: Yuan Liu, Xue-chun Wang, Dan Hu, Shu-ran Huang, Qing-shu Li, Zhi Li, Yan Qu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; exogenous heat shock protein 70; lentivirus transfection; ischemia-hypoxia/reoxygenation; PC12 cells; Ca2+ endoplasmic reticulum; inositol 145-trisphosphate receptor; sarcoplasmic/endoplasmic reticulum Ca2+-ATPase; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=7;spage=1134;epage=1140;aulast=Liu

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=7;spage=1134;epage=1140;aulast=Liu

Similar Items