REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis

REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis

The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases expression of complement genes, including C4b and C3, in the hippocampus. BMAL1 regulates expression...

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Bibliographic Details
Main Authors: Percy Griffin, Patrick W Sheehan, Julie M Dimitry, Chun Guo, Michael F Kanan, Jiyeon Lee, Jinsong Zhang, Erik S Musiek
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
circadian rhythm
synaptic terminals
complement
neuron-glia interactions
Online Access:https://elifesciences.org/articles/58765

Internet

https://elifesciences.org/articles/58765

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