Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein

Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein

Lipid nanoparticles (LNPs) are the most clinically advanced delivery system for RNA-based drugs but have predominantly been investigated for intravenous and intramuscular administration. Subcutaneous administration opens the possibility of patient self-administration and hence long-term chronic trea...

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Bibliographic Details
Main Authors: Nigel Davies, Daniel Hovdal, Nicholas Edmunds, Peter Nordberg, Anders Dahlén, Aleksandra Dabkowska, Marianna Yanez Arteta, Aurel Radulescu, Tomas Kjellman, Andreas Höijer, Frank Seeliger, Elin Holmedal, Elisabeth Andihn, Nils Bergenhem, Ann-Sofie Sandinge, Camilla Johansson, Leif Hultin, Marie Johansson, Johnny Lindqvist, Liselotte Björsson, Yujia Jing, Stefano Bartesaghi, Lennart Lindfors, Shalini Andersson
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
LNP
mRNA
subcutaneous delivery
FGF21
steroid prodrug
tolerability
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000792

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http://www.sciencedirect.com/science/article/pii/S2162253121000792

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