von Willebrand factor links primary hemostasis to innate immunity

von Willebrand factor links primary hemostasis to innate immunity

von Willebrand factor (VWF) plays a critical role in primary hemostasis following vascular injury by tethering platelets to exposed collagen. Here, VWF binding to macrophages is shown to trigger NF-κB activation and induce pro-inflammatory responses.

Bibliographic Details
Main Authors: Clive Drakeford, Sonia Aguila, Fiona Roche, Karsten Hokamp, Judicael Fazavana, Mariana P. Cervantes, Annie M. Curtis, Heike C. Hawerkamp, Sukhraj Pal Singh Dhami, Hugo Charles-Messance, Emer E. Hackett, Alain Chion, Soracha Ward, Azaz Ahmad, Ingmar Schoen, Eamon Breen, Joe Keane, Ross Murphy, Roger J. S. Preston, Jamie M. O’Sullivan, Frederick J. Sheedy, Padraic Fallon, James S. O’Donnell
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33796-7

Internet

https://doi.org/10.1038/s41467-022-33796-7

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