Quiescent innate and adaptive immune responses maintain the long-term integrity of corneal endothelium reconstituted through allogeneic cell injection therapy

Abstract This study aims to clarify the immunogenicity in acquired and innate immune responses of cultured human corneal endothelial cells (hCECs) applied for cell injection therapy, a newly established modality for corneal endothelium failures. Thirty-four patients with corneal endothelial failure...

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Bibliographic Details
Main Authors: Munetoyo Toda, Morio Ueno, Jun Yamada, Asako Hiraga, Kazuko Asada, Junji Hamuro, Chie Sotozono, Shigeru Kinoshita
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-22522-4