Pharmacokinetic assessment of pyrazinamide and pyrazinoic acid in carbon tetrachloride-induced liver injury model in Wistar Rats

Pharmacokinetic assessment of pyrazinamide and pyrazinoic acid in carbon tetrachloride-induced liver injury model in Wistar Rats

Background: We investigated the pharmacokinetic behavior of pyrazinamide (PZA) and pyrazinoic acid (PA) in the presence of carbon-tetrachloride (CCl4) plus antitubercular treatment (ATT) drug-induced liver injury (DILI) in rats. Methods: Thirty rats utilized in the experiment were separated equally...

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Bibliographic Details
Main Authors: Swati Sharma, Vishal Sharma, Sunil Taneja, Alka Bhatia, Aishwarya Anand, Dibyajyoti Banerjee, Amol N Patil
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Journal of Pharmacy and Bioallied Sciences
Subjects:
carbon tetrachloride
liver injury
pharmacokinetics
pharmacometabolomics
pharmacometabonomics
pyrazinamide
pyrazines acid
therapeutic drug monitoring
Online Access:http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=3;spage=146;epage=151;aulast=Sharma

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http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=3;spage=146;epage=151;aulast=Sharma

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