Loss of circadian clock accelerates aging in neurodegeneration-prone mutants

Loss of circadian clock accelerates aging in neurodegeneration-prone mutants

Circadian clocks generate rhythms in molecular, cellular, physiological, and behavioral processes. Recent studies suggest that disruption of the clock mechanism accelerates organismal senescence and age-related pathologies in mammals. Impaired circadian rhythms are observed in many neurological dise...

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Bibliographic Details
Main Authors: Natraj Krishnan, Kuntol Rakshit, Eileen S. Chow, Jill S. Wentzell, Doris Kretzschmar, Jadwiga M. Giebultowicz
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Neurobiology of Disease
Subjects:
Biological clock
Circadian rhythms
Neuronal health
Protein carbonyls
RING assay
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111004098

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http://www.sciencedirect.com/science/article/pii/S0969996111004098

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