Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

<p>Abstract</p> <p>Background</p> <p>Betulinic acid (BA) inhibits growth of several cancer cell lines and tumors and the effects of BA have been attributed to its mitochondriotoxicity and inhibition of multiple pro-oncogenic factors. Previous studies show that BA induce...

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Bibliographic Details
Main Authors: Pathi Satya, Lei Ping, Papineni Sabitha, Chintharlapalli Sudhakar, Safe Stephen
Format: Article
Language:English
Published: BMC 2011-08-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/11/371

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