Lysine methylation promotes NFAT5 activation and determines temozolomide efficacy in glioblastoma

Lysine methylation promotes NFAT5 activation and determines temozolomide efficacy in glioblastoma

Abstract Temozolomide (TMZ) therapy offers minimal clinical benefits in patients with glioblastoma multiforme (GBM) with high EGFR activity, underscoring the need for effective combination therapy. Here, we show that tonicity-responsive enhancer binding protein (NFAT5) lysine methylation, is a deter...

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Bibliographic Details
Main Authors: Yatian Li, Zhenyue Gao, Yuhong Wang, Bo Pang, Binbin Zhang, Ruxin Hu, Yuqing Wang, Chao Liu, Xuebin Zhang, Jingxuan Yang, Mei Mei, Yongzhi Wang, Xuan Zhou, Min Li, Yu Ren
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39845-z

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https://doi.org/10.1038/s41467-023-39845-z

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