Dissecting transcriptional amplification by MYC

Dissecting transcriptional amplification by MYC

Supraphysiological MYC levels are oncogenic. Originally considered a typical transcription factor recruited to E-boxes (CACGTG), another theory posits MYC a global amplifier increasing output at all active promoters. Both models rest on large-scale genome-wide ”-omics’. Because the assumptions, stat...

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Bibliographic Details
Main Authors: Zuqin Nie, Chunhua Guo, Subhendu K Das, Carson C Chow, Eric Batchelor, S Stoney Simons Jnr, David Levens
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
MYC
transcription
cancer
general amplifier
michaelis-menten kinetics
kinetic mechanism of action
Online Access:https://elifesciences.org/articles/52483

Internet

https://elifesciences.org/articles/52483

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