Dissecting transcriptional amplification by MYC
Supraphysiological MYC levels are oncogenic. Originally considered a typical transcription factor recruited to E-boxes (CACGTG), another theory posits MYC a global amplifier increasing output at all active promoters. Both models rest on large-scale genome-wide ”-omics’. Because the assumptions, stat...
Main Authors: | Zuqin Nie, Chunhua Guo, Subhendu K Das, Carson C Chow, Eric Batchelor, S Stoney Simons Jnr, David Levens |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-07-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/52483 |
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