All-trans retinoic acid improves NSD2-mediated RARα phase separation and efficacy of anti-CD38 CAR T-cell therapy in multiple myeloma

All-trans retinoic acid improves NSD2-mediated RARα phase separation and efficacy of anti-CD38 CAR T-cell therapy in multiple myeloma

Background Immunotherapies targeting CD38 have demonstrated salient efficacy in relapsed/refractory multiple myeloma (MM). However, loss of CD38 antigen and outgrowth of CD38 negative plasma cells have emerged as a major obstacle in clinics. All-trans retinoic acid (ATRA) has been reported to upregu...

Full description

Bibliographic Details
Main Authors: Jing Guo, Xin Li, Hongmei Jiang, Jingya Wang, Zhiqiang Liu, Sheng Wang, Ying Xie, Yafei Wang, Mengqi Wang, Ziyi Peng, Yixuan Wang, Meilin Hu, Jian-Qing Mi
Format: Article
Language:English
Published: BMJ Publishing Group 2023-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/3/e006325.full

Internet

https://jitc.bmj.com/content/11/3/e006325.full

Similar Items