Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial

Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial

Abstract Objective Neurological and functional impairments are commonly observed in individuals with spinal cord injury (SCI) due to insufficient regeneration of damaged axons. Exosomes play a crucial role in the paracrine effects of mesenchymal stem cells (MSCs) and have emerged as a promising ther...

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Bibliographic Details
Main Authors: Mohammadhosein Akhlaghpasand, Roozbeh Tavanaei, Maede Hosseinpoor, Kaveh Oraii Yazdani, Afsane Soleimani, Mojtaba Yousefi Zoshk, Masoud Soleimani, Mohsen Chamanara, Mahdi Ghorbani, Mohammad Deylami, Alireza Zali, Reza Heidari, Saeed Oraee-Yazdani
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Stem Cell Research & Therapy
Subjects:
Spinal cord injury
Exosomes
Mesenchymal stem cells
Neuroprotection
Online Access:https://doi.org/10.1186/s13287-024-03868-0

Internet

https://doi.org/10.1186/s13287-024-03868-0

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