Development of the First <sup>18</sup>F-Labeled Radiohybrid-Based Minigastrin Derivative with High Target Affinity and Tumor Accumulation by Substitution of the Chelating Moiety

Development of the First <sup>18</sup>F-Labeled Radiohybrid-Based Minigastrin Derivative with High Target Affinity and Tumor Accumulation by Substitution of the Chelating Moiety

In order to optimize elevated kidney retention of previously reported minigastrin derivatives, we substituted (<i>R</i>)-DOTAGA by DOTA in (<i>R</i>)-DOTAGA-rhCCK-16/-18. CCK-2R-mediated internalization and affinity of the new compounds were determined using AR42J cells. Biod...

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Bibliographic Details
Main Authors: Thomas Günther, Nadine Holzleitner, Daniel Di Carlo, Nicole Urtz-Urban, Constantin Lapa, Hans-Jürgen Wester
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
cholecystokinin-2 receptor (CCK-2R)
cholecystokinin-B receptor (CCK-BR)
MTC
<sup>18</sup>F-labeled minigastrin analogs
radiohybrid
rhCCK
Online Access:https://www.mdpi.com/1999-4923/15/3/826

Internet

https://www.mdpi.com/1999-4923/15/3/826

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