The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold

The enterococcal cytolysin is a virulence factor consisting of two post-translationally modified peptides that synergistically kill human immune cells. Both peptides are made by CylM, a member of the LanM lanthipeptide synthetases. CylM catalyzes seven dehydrations of Ser and Thr residues and three...

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Bibliographic Details
Main Authors: Shi-Hui Dong, Weixin Tang, Tiit Lukk, Yi Yu, Satish K Nair, Wilfred A van der Donk
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/07607