Origin, diversity and maturation of human antiviral antibodies analyzed by high-throughput sequencing

Origin, diversity and maturation of human antiviral antibodies analyzed by high-throughput sequencing

Our understanding of how antibodies are generated and function could help develop effective vaccines and antibody-based therapeutics against viruses such as HIV-1, SARS Coronavirus (CoV), and Hendra and Nipah viruses (henipaviruses). Although broadly neutralizing antibodies (bnAbs) against the HIV-1...

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Bibliographic Details
Main Authors: Ponraj ePrabakaran, Zhongyu eZhu, Weizao eChen, Rui eGong, Yang eFeng, Emily eStreaker, Dimiter S Dimitrov
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Microbiology
Subjects:
HIV-1
Immunogenetics
Vaccines
monoclonal antibodies
IgM
immunogen
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00277/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00277/full

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