Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development

Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development

Lysyl oxidase-like 2 (LOXL2) and 3 (LOXL3) are members of the lysyl oxidase family of enzymes involved in the maturation of the extracellular matrix. Both enzymes share a highly conserved catalytic domain, but it is unclear whether they perform redundant functions in vivo. In this study, we show tha...

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Bibliographic Details
Main Authors: Patricia G. Santamaría, Pierre Dubus, José Bustos-Tauler, Alfredo Floristán, Alberto Vázquez-Naharro, Saleta Morales, Amparo Cano, Francisco Portillo
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
lysyl oxidases
Loxl2
Loxl3
epistasis analysis
embryonic lethality
Online Access:https://www.mdpi.com/1422-0067/23/10/5730

Internet

https://www.mdpi.com/1422-0067/23/10/5730

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