Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/PAD4 pathway

Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/PAD4 pathway

Both cholinergic dysfunction and protein citrullination are the hallmarks of rheumatoid arthritis (RA), but the relationship between the two phenomena remains unclear. We explored whether and how cholinergic dysfunction accelerates protein citrullination and consequently drives the development of RA...

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Bibliographic Details
Main Authors: Changjun Lv, Minghui Sun, Yilei Guo, Wenxin Xia, Simiao Qiao, Yu Tao, Yulai Fang, Qin Zhang, Yanrong Zhu, Yusufu Yalikun, Yufeng Xia, Zhifeng Wei, Yue Dai
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Rheumatoid arthritis
Citrullination
Cholinergic dysfunction
α7nAChR
Peptidylarginine deiminase 4
Specificity protein-3
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523000163

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http://www.sciencedirect.com/science/article/pii/S2211383523000163

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