A Brownian ratchet model for DNA loop extrusion by the cohesin complex

A Brownian ratchet model for DNA loop extrusion by the cohesin complex

The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities. ATP and DNA binding promote cohesin conformational chan...

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Bibliographic Details
Main Authors: Torahiko L Higashi, Georgii Pobegalov, Minzhe Tang, Maxim I Molodtsov, Frank Uhlmann
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
Cohesin
SMC complexes
sister chromatid cohesion
DNA loop extrusion
structural biology
biophysical simulation
Online Access:https://elifesciences.org/articles/67530

Internet

https://elifesciences.org/articles/67530

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