Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression

Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression

Cells respond to inflammatory stimuli such as cytokines by activation of the nuclear factor-κB (NF-κB) signalling pathway, resulting in oscillatory translocation of the transcription factor p65 between nucleus and cytoplasm in some cell types. We investigate the relationship between p65 and inhibito...

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Bibliographic Details
Main Authors: Polly Downton, James S. Bagnall, Hazel England, David G. Spiller, Neil E. Humphreys, Dean A. Jackson, Pawel Paszek, Michael R. H. White, Antony D. Adamson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
NF-κB
inflammation
IκB⍺
overexpression
gene expression
localisation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1187187/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1187187/full

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