Computational tumor stroma reaction evaluation led to novel prognosis-associated fibrosis and molecular signature discoveries in high-grade serous ovarian carcinoma

BackgroundAs one of the key criteria to differentiate benign vs. malignant tumors in ovarian and other solid cancers, tumor-stroma reaction (TSR) is long observed by pathologists and has been found correlated with patient prognosis. However, paucity of study aims to overcome subjective bias or autom...

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Bibliographic Details
Main Authors: Jun Jiang, Burak Tekin, Lin Yuan, Sebastian Armasu, Stacey J. Winham, Ellen L. Goode, Hongfang Liu, Yajue Huang, Ruifeng Guo, Chen Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.994467/full