The Microtubule-Targeting Agent Pretubulysin Impairs the Inflammatory Response in Endothelial Cells by a JNK-Dependent Deregulation of the Histone Acetyltransferase Brd4

The Microtubule-Targeting Agent Pretubulysin Impairs the Inflammatory Response in Endothelial Cells by a JNK-Dependent Deregulation of the Histone Acetyltransferase Brd4

The anti-inflammatory effects of depolymerizing microtubule-targeting agents on leukocytes are known for a long time, but the potential involvement of the vascular endothelium and the underlying mechanistic basis is still largely unclear. Using the recently synthesized depolymerizing microtubule-tar...

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Bibliographic Details
Main Authors: Tobias F. Primke, Rebecca Ingelfinger, Mohammed A. F. Elewa, Igor Macinkovic, Andreas Weigert, Matthias P. Fabritius, Christoph A. Reichel, Angelika Ullrich, Uli Kazmaier, Luisa D. Burgers, Robert Fürst
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
inflammation
endothelium
leukocyte adhesion cascade
cell adhesion molecules
microtubule-targeting agents
c-jun-N-terminal kinase
Online Access:https://www.mdpi.com/2073-4409/12/16/2112

Internet

https://www.mdpi.com/2073-4409/12/16/2112

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