Clozapine Reverses Dysfunction of Glutamatergic Neurons Derived From Clozapine-Responsive Schizophrenia Patients

Clozapine Reverses Dysfunction of Glutamatergic Neurons Derived From Clozapine-Responsive Schizophrenia Patients

The cellular pathology of schizophrenia and the potential of antipsychotics to target underlying neuronal dysfunctions are still largely unknown. We employed glutamatergic neurons derived from induced pluripotent stem cells (iPSC) obtained from schizophrenia patients with known histories of response...

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Bibliographic Details
Main Authors: Hana Hribkova, Ondrej Svoboda, Elis Bartecku, Jana Zelinkova, Jana Horinkova, Lubica Lacinova, Martin Piskacek, Bretislav Lipovy, Ivo Provaznik, Joel C. Glover, Tomas Kasparek, Yuh-Man Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
schizophrenia
clozapine
hiPSC
glutamate
neuron
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.830757/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.830757/full

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