Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity

Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity

The neurotransmitter acetylcholine has been implicated in reward learning and drug addiction. However, the roles of the various cholinergic receptor subtypes on different neuron populations remain elusive. Here we study the function of muscarinic M4 receptors (M4Rs) in dopamine D1 receptor (D1R) exp...

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Bibliographic Details
Main Authors: Anna M. Klawonn, Daniel B. Wilhelms, Sarah H. Lindström, Anand Kumar Singh, Maarit Jaarola, Jürgen Wess, Michael Fritz, David Engblom
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
muscarinic M4 receptor
acetylcholine
dopamine D1 receptor
reward learning
impulsivity
addiction
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00139/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00139/full

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