Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and Fluorescence Spectroscopies

Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and Fluorescence Spectroscopies

The low water solubility of baricitinib (BCT) limits the development of new formulations for the topical delivery of the drug. The aims of this study were to assess the solubility of BCT in different solvents, including Transcutol, a biocompatible permeation enhancer that is miscible in water, to ev...

Full description

Bibliographic Details
Main Authors: Roya Mohammadi-Meyabadi, Negar Beirampour, Núria Garrós, Helen Lissette Alvarado, David Limón, Marcelle Silva-Abreu, Ana Cristina Calpena, Mireia Mallandrich
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
baricitinib
poorly water-soluble drug
solubility study
stability study
in vitro tissue uptake
fluorescence spectroscopy
Online Access:https://www.mdpi.com/1999-4923/14/12/2714

Internet

https://www.mdpi.com/1999-4923/14/12/2714

Similar Items