Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling

Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling

Summary: Background: Sarcolipin and uncoupling protein 3 (UCP3) mediate muscle-based non-shivering thermogenesis (NST) to improve metabolic homeostasis. The impacts of maternal obesity (MO) and maternal exercise (ME) on NST in offspring muscle remain unexamined. Methods: Female mice were fed with a...

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Bibliographic Details
Main Authors: Jun Seok Son, Song Ah Chae, Liang Zhao, Hongyang Wang, Jeanene M. de Avila, Mei-Jun Zhu, Zhihua Jiang, Min Du
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:EBioMedicine
Subjects:
Maternal obesity
Sarcolipin
UCP3
PGC-1α
Calcium activity
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422000263

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http://www.sciencedirect.com/science/article/pii/S2352396422000263

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