Efficacy of a third-generation oncolytic herpes simplex virus in refractory soft tissue sarcoma xenograft models

Efficacy of a third-generation oncolytic herpes simplex virus in refractory soft tissue sarcoma xenograft models

Malignant soft tissue tumors, particularly highly malignant leiomyosarcomas, are resistant to chemotherapy and associated with a poor prognosis. T-01, a third-generation genetically modified herpes simplex virus type 1, replicates in tumor cells alone and exerts a cell-killing effect. The current st...

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Bibliographic Details
Main Authors: Masahiko Hatta, Masaki Kaibori, Hideyuki Matsushima, Terufumi Yoshida, Tadayoshi Okumura, Mikio Hayashi, Kengo Yoshii, Tomoki Todo, Mitsugu Sekimoto
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic virus
herpes simplex virus
T-01
malignant soft tissue tumor
mouse xenograft model
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522000626

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http://www.sciencedirect.com/science/article/pii/S2372770522000626

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