Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves

Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves

Summary: Glucose-responsive ATP-sensitive potassium channels (KATP) are expressed in a variety of tissues including nervous systems. The depolarization of the membrane potential induced by glucose may lead to hyperexcitability of neurons and induce excitotoxicity. However, the roles of KATP in the p...

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Bibliographic Details
Main Authors: Hiromi Nakai-Shimoda, Tatsuhito Himeno, Tetsuji Okawa, Emiri Miura-Yura, Sachiko Sasajima, Makoto Kato, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Rieko Inoue, Masaki Kondo, Susumu Seino, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:iScience
Subjects:
Molecular neuroscience
Cellular neuroscience
Sensory neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221015790

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http://www.sciencedirect.com/science/article/pii/S2589004221015790

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